Protease Inhibitors (PIs)

Brief information about it:
Ritonavir is a protease inhibitor (PI) medication used to treat HIV/AIDS.
Uses:
· Treatment of HIV/AIDS
· Booster for other antiretroviral medications (drug-drug interaction booster)
Mechanism of action:
Ritonavir inhibits HIV protease, an enzyme essential for the virus to mature and infect new cells. By blocking this enzyme, ritonavir prevents the virus from replicating.
Elimination half life:
Approximately 3-5 hours
Route of Administration:
Oral (capsules, solution, tablets)
Side effects:
Common side effects of ritonavir include:
- Diarrhea
- Nausea
- Vomiting
- Headache
- Fatigue
- Rash
- Changes in body fat distribution
More serious side effects, although rare, can include:
- Liver damage
- Pancreatitis
- Kidney problems
- Heart problems
Dose:
The dosage of ritonavir varies depending on the individual and the specific treatment regimen. It is often used in combination with other antiretroviral drugs to boost their effectiveness.
Precautions:
· Liver Function: Ritonavir can affect liver function, so regular monitoring of liver enzymes is necessary.
· Drug Interactions: Ritonavir can interact with many other medications, so it’s important to inform your healthcare provider about all medications you are taking.
· Side Effects: Be aware of the potential side effects and consult with your healthcare provider if you experience any concerning symptoms.