HIV Treatments

Protease Inhibitors (PIs)

Brief information about it:

Ritonavir is a protease inhibitor (PI) medication used to treat HIV/AIDS.

Uses:

·  Treatment of HIV/AIDS

·  Booster for other antiretroviral medications (drug-drug interaction booster)

Mechanism of action:

Ritonavir inhibits HIV protease, an enzyme essential for the virus to mature and infect new cells. By blocking this enzyme, ritonavir prevents the virus from replicating.

Elimination half life:

Approximately 3-5 hours

Route of Administration:

Oral (capsules, solution, tablets)

Side effects:

Common side effects of ritonavir include:

  • Diarrhea
  • Nausea
  • Vomiting
  • Headache
  • Fatigue
  • Rash
  • Changes in body fat distribution

More serious side effects, although rare, can include:

  • Liver damage
  • Pancreatitis
  • Kidney problems
  • Heart problems

Dose:

The dosage of ritonavir varies depending on the individual and the specific treatment regimen. It is often used in combination with other antiretroviral drugs to boost their effectiveness.

Precautions:

·  Liver Function: Ritonavir can affect liver function, so regular monitoring of liver enzymes is necessary.

·  Drug Interactions: Ritonavir can interact with many other medications, so it’s important to inform your healthcare provider about all medications you are taking.

·  Side Effects: Be aware of the potential side effects and consult with your healthcare provider if you experience any concerning symptoms.

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